Definition
Leptin is an appetite regulating hormone produced by fat cells that helps the brain signals fullness. It opposes the hormone ghrelin which stimulates hunger.
Explanation
- As fat cells size increases, more leptin is released to diminish appetite. This mechanism can malfunction leading to leptin resistance.
- High leptin levels indicate sufficient energy storage and excess body fat. Low leptin increases appetite and food seeking.
- Sleep deprivation, stress, inflammation, and insulin resistance can blunt leptin function, overriding satiety signals.
- To improve leptin response, focus on sleep, exercise, and limiting processed foods. Leptin reset diets may temporarily restore sensitivity.
Examples
- Feeling constantly hungry and overeating despite excess body fat and high leptin levels.
- Leptin levels plummeting during extreme diet deprivation, increasing hunger.
Related Terms
- Ghrelin, obesity, satiety hormone, hunger cues
Common Questions
- How can I reset my leptin? Get 7-9 hours of sleep, walk daily, eat fatty fish, and avoid sugar/processed carbs.
- Do I want high or low leptin? Ideal leptin levels promote feeling full and weight regulation without overeating.
Do Not Confuse With
- Ghrelin – The opposing hormone that increases appetite and hunger.
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